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TRPM2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O94759
Clone Names 100430286
Peptide ID 100430286
Additional Information
Gene ID 7226
Other Names Transient receptor potential cation channel subfamily M member 2, Estrogen-responsive element-associated gene 1 protein, Long transient receptor potential channel 2, LTrpC-2, LTrpC2, Transient receptor potential channel 7, TrpC7, TRPM2, EREG1, KNP3, LTRPC2, TRPC7
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPM2
Synonyms EREG1, KNP3, LTRPC2, TRPC7
Function Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.
Research Areas
Citations (0)

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The protein encoded by this gene is a calcium-permeablecation channel that is regulated by free intracellular ADP-ribose.The encoded protein is activated by oxidative stress and conferssusceptibility to cell death. Several alternatively splicedtranscript variants of this gene have been described, but theirfull-length nature is not known.


Romero, J.R., et al. Clin. Chim. Acta 411 (19-20), 1437-1440 (2010) :Yang, W., et al. J. Biol. Chem. 285(40):30411-30418(2010)Toth, B., et al. J. Biol. Chem. 285(39):30091-30102(2010)Kuhn, F.J., et al. J. Biol. Chem. 285(35):26806-26814(2010)Hong, C.W., et al. J. Immunol. 184(8):4401-4413(2010)

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$ 80.00
Cat# BP14200b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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