|Other Names||Transient receptor potential cation channel subfamily M member 2, Estrogen-responsive element-associated gene 1 protein, Long transient receptor potential channel 2, LTrpC-2, LTrpC2, Transient receptor potential channel 7, TrpC7, TRPM2, EREG1, KNP3, LTRPC2, TRPC7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||EREG1, KNP3, LTRPC2, TRPC7|
|Function||Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a calcium-permeablecation channel that is regulated by free intracellular ADP-ribose.The encoded protein is activated by oxidative stress and conferssusceptibility to cell death. Several alternatively splicedtranscript variants of this gene have been described, but theirfull-length nature is not known.
Romero, J.R., et al. Clin. Chim. Acta 411 (19-20), 1437-1440 (2010) :Yang, W., et al. J. Biol. Chem. 285(40):30411-30418(2010)Toth, B., et al. J. Biol. Chem. 285(39):30091-30102(2010)Kuhn, F.J., et al. J. Biol. Chem. 285(35):26806-26814(2010)Hong, C.W., et al. J. Immunol. 184(8):4401-4413(2010)
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