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TRIP6 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15654 |
|---|---|
| Clone Names | 100430336 |
| Gene ID | 7205 |
|---|---|
| Other Names | Thyroid receptor-interacting protein 6, TR-interacting protein 6, TRIP-6, Opa-interacting protein 1, OIP-1, Zyxin-related protein 1, ZRP-1, TRIP6, OIP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TRIP6 |
|---|---|
| Synonyms | OIP1 |
| Function | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF- kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm Note=Shuttles between nucleus and cytoplasm (PubMed:16624523) Colocalizes with actin (PubMed:10826496). |
| Tissue Location | Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the zyxin family and encodes aprotein with three LIM zinc-binding domains. This protein localizesto focal adhesion sites and along actin stress fibers. Recruitmentof this protein to the plasma membrane occurs in a lysophosphatidicacid (LPA)-dependent manner and it regulates LPA-induced cellmigration. Alternatively spliced variants which encode differentprotein isoforms have been described; however, not all variantshave been fully characterized.
References
Shanmugarajan, S., et al. J. Cell. Biochem. 107(1):104-111(2009)Chastre, E., et al. FASEB J. 23(3):916-928(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Shanmugarajan, S., et al. J. Cell. Biochem. 104(4):1500-1508(2008)Bai, C.Y., et al. J. Cell. Sci. 120 (PT 16), 2828-2837 (2007) :
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