|Other Names||Thyroid receptor-interacting protein 6, TR-interacting protein 6, TRIP-6, Opa-interacting protein 1, OIP-1, Zyxin-related protein 1, ZRP-1, TRIP6, OIP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus Cytoplasm. Note=Shuttles between nucleus and cytoplasm (PubMed:16624523). Colocalizes with actin (PubMed:10826496).|
|Tissue Location||Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the zyxin family and encodes aprotein with three LIM zinc-binding domains. This protein localizesto focal adhesion sites and along actin stress fibers. Recruitmentof this protein to the plasma membrane occurs in a lysophosphatidicacid (LPA)-dependent manner and it regulates LPA-induced cellmigration. Alternatively spliced variants which encode differentprotein isoforms have been described; however, not all variantshave been fully characterized.
Shanmugarajan, S., et al. J. Cell. Biochem. 107(1):104-111(2009)Chastre, E., et al. FASEB J. 23(3):916-928(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Shanmugarajan, S., et al. J. Cell. Biochem. 104(4):1500-1508(2008)Bai, C.Y., et al. J. Cell. Sci. 120 (PT 16), 2828-2837 (2007) :
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