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TRIP6 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15654
Clone Names 100430336
Peptide ID 100430336
Additional Information
Gene ID 7205
Other Names Thyroid receptor-interacting protein 6, TR-interacting protein 6, TRIP-6, Opa-interacting protein 1, OIP-1, Zyxin-related protein 1, ZRP-1, TRIP6, OIP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIP6
Synonyms OIP1
Function Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
Cellular Location Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus Cytoplasm. Note=Shuttles between nucleus and cytoplasm (PubMed:16624523). Colocalizes with actin (PubMed:10826496).
Tissue Location Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors
Research Areas
Citations (0)

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This gene is a member of the zyxin family and encodes aprotein with three LIM zinc-binding domains. This protein localizesto focal adhesion sites and along actin stress fibers. Recruitmentof this protein to the plasma membrane occurs in a lysophosphatidicacid (LPA)-dependent manner and it regulates LPA-induced cellmigration. Alternatively spliced variants which encode differentprotein isoforms have been described; however, not all variantshave been fully characterized.


Shanmugarajan, S., et al. J. Cell. Biochem. 107(1):104-111(2009)Chastre, E., et al. FASEB J. 23(3):916-928(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Shanmugarajan, S., et al. J. Cell. Biochem. 104(4):1500-1508(2008)Bai, C.Y., et al. J. Cell. Sci. 120 (PT 16), 2828-2837 (2007) :

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$ 80.00
Cat# BP14201a
Availability: In Stock
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