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DUT Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P33316
Clone Names 100430342
Additional Information
Gene ID 1854
Other Names Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, dUTPase, dUTP pyrophosphatase, DUT
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUT
Function Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator- activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity).
Cellular Location [Isoform 2]: Nucleus
Tissue Location Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level)
Research Areas
Citations (0)
citation

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Background

This gene encodes an essential enzyme of nucleotidemetabolism. The encoded protein forms a ubiquitous, homotetramericenzyme that hydrolyzes dUTP to dUMP and pyrophosphate. Thisreaction serves two cellular purposes: providing a precursor (dUMP)for the synthesis of thymine nucleotides needed for DNAreplication, and limiting intracellular pools of dUTP. Elevatedlevels of dUTP lead to increased incorporation of uracil into DNA,which induces extensive excision repair mediated by uracilglycosylase. This repair process, resulting in the removal andreincorporation of dUTP, is self-defeating and leads to DNAfragmentation and cell death. Alternative splicing of this geneleads to different isoforms that localize to either themitochondrion or nucleus. A related pseudogene is located onchromosome 19.

References

Takatori, H., et al. Liver Int. 30(3):438-446(2010)Quesada-Soriano, I., et al. Biochimie 92(2):178-186(2010)Chanson, A., et al. Am. J. Clin. Nutr. 89(6):1927-1936(2009)Takacs, E., et al. FEBS Lett. 583(5):865-871(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)

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$ 277.78
Cat# BP14203b
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