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NR2E3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y5X4 |
|---|---|
| Clone Names | 100507007 |
| Gene ID | 10002 |
|---|---|
| Other Names | Photoreceptor-specific nuclear receptor, Nuclear receptor subfamily 2 group E member 3, Retina-specific nuclear receptor, NR2E3, PNR, RNR |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NR2E3 |
|---|---|
| Synonyms | PNR, RNR |
| Function | Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:15689355} |
| Tissue Location | Eye specific; found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein is part of a large family of nuclear receptortranscription factors involved in signaling pathways. Nuclearreceptors have been shown to regulate pathways involved inembryonic development, as well as in maintenance of proper cellfunction in adults. Members of this family are characterized bydiscrete domains that function in DNA and ligand binding. This geneencodes a retinal nuclear receptor that is a ligand-dependenttranscription factor. Defects in this gene are a cause of enhancedS cone syndrome. Alternatively spliced transcript variants encodingdifferent isoforms have been identified.
References
Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)Yang, Y., et al. Invest. Ophthalmol. Vis. Sci. 51(4):2229-2235(2010)Khan, A.O., et al. Arch. Ophthalmol. 128(3):344-348(2010)Kanda, A., et al. Mol. Vis. 15, 2174-2184 (2009) :Roduit, R., et al. PLoS ONE 4 (10), E7379 (2009) :
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