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NR2E3 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y5X4
Clone Names 100507007
Peptide ID 100507007
Additional Information
Gene ID 10002
Other Names Photoreceptor-specific nuclear receptor, Nuclear receptor subfamily 2 group E member 3, Retina-specific nuclear receptor, NR2E3, PNR, RNR
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR2E3
Synonyms PNR, RNR
Function Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:15689355}
Tissue Location Eye specific; found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside
Research Areas
Citations (0)

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This protein is part of a large family of nuclear receptortranscription factors involved in signaling pathways. Nuclearreceptors have been shown to regulate pathways involved inembryonic development, as well as in maintenance of proper cellfunction in adults. Members of this family are characterized bydiscrete domains that function in DNA and ligand binding. This geneencodes a retinal nuclear receptor that is a ligand-dependenttranscription factor. Defects in this gene are a cause of enhancedS cone syndrome. Alternatively spliced transcript variants encodingdifferent isoforms have been identified.


Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)Yang, Y., et al. Invest. Ophthalmol. Vis. Sci. 51(4):2229-2235(2010)Khan, A.O., et al. Arch. Ophthalmol. 128(3):344-348(2010)Kanda, A., et al. Mol. Vis. 15, 2174-2184 (2009) :Roduit, R., et al. PLoS ONE 4 (10), E7379 (2009) :

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$ 80.00
Cat# BP14205c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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