|Other Names||Matrin-3, MATR3, KIAA0723|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.|
|Cellular Location||Nucleus matrix.|
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This locus encodes a nuclear matrix protein. Mutations atthis locus have been associated with distal myopathy 2, which oftenincludes vocal cord and pharyngeal weakness. Alternatively splicedtranscript variants, including read-through transcripts with anupstream locus have been described. Related pseuodgenses have beendefined on chr1 and chrX.
Zeitz, M.J., et al. J. Cell. Biochem. 108(1):125-133(2009)Senderek, J., et al. Am. J. Hum. Genet. 84(4):511-518(2009)Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009) :Malyavantham, K.S., et al. J. Cell. Biochem. 105(2):391-403(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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