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MATR3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P43243 |
|---|---|
| Clone Names | 100507009 |
| Gene ID | 9782 |
|---|---|
| Other Names | Matrin-3, MATR3, KIAA0723 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MATR3 |
|---|---|
| Synonyms | KIAA0723 |
| Function | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). |
| Cellular Location | Nucleus matrix. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This locus encodes a nuclear matrix protein. Mutations atthis locus have been associated with distal myopathy 2, which oftenincludes vocal cord and pharyngeal weakness. Alternatively splicedtranscript variants, including read-through transcripts with anupstream locus have been described. Related pseuodgenses have beendefined on chr1 and chrX.
References
Zeitz, M.J., et al. J. Cell. Biochem. 108(1):125-133(2009)Senderek, J., et al. Am. J. Hum. Genet. 84(4):511-518(2009)Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009) :Malyavantham, K.S., et al. J. Cell. Biochem. 105(2):391-403(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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