|Other Names||Junctional adhesion molecule B, JAM-B, Junctional adhesion molecule 2, JAM-2, Vascular endothelial junction-associated molecule, VE-JAM, CD322, JAM2, C21orf43, VEJAM|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the processes of lymphocyte homing to secondary lymphoid organs.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.|
|Tissue Location||Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells.|
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Tight junctions represent one mode of cell-to-celladhesion in epithelial or endothelial cell sheets, formingcontinuous seals around cells and serving as a physical barrier toprevent solutes and water from passing freely through theparacellular space. The protein encoded by this immunoglobulinsuperfamily gene member is localized in the tight junctions betweenhigh endothelial cells. It acts as an adhesive ligand forinteracting with a variety of immune cell types and may play a rolein lymphocyte homing to secondary lymphoid organs. [provided byRefSeq].
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Ueki, T., et al. Microvasc. Res. 75(2):269-278(2008)Weber, C., et al. Nat. Rev. Immunol. 7(6):467-477(2007)Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
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