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FZD5 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13467 |
|---|---|
| Clone Names | 100507018 |
| Gene ID | 7855 |
|---|---|
| Other Names | Frizzled-5, Fz-5, hFz5, FzE5, FZD5, C2orf31 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FZD5 |
|---|---|
| Synonyms | C2orf31 |
| Function | Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8CHL0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8CHL0}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9EQD0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9EQD0}. Synapse {ECO:0000250|UniProtKB:Q8CHL0}. Perikaryon {ECO:0000250|UniProtKB:Q8CHL0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8CHL0}. Cell projection, axon {ECO:0000250|UniProtKB:Q8CHL0}. Note=Localized at the plasma membrane and also found at the Golgi. {ECO:0000250|UniProtKB:Q9EQD0} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the 'frizzled' gene family encode7-transmembrane domain proteins that are receptors for Wntsignaling proteins. The FZD5 protein is believed to be thereceptor for the Wnt5A ligand.
References
Moller, M., et al. BMC Infect. Dis. 10, 154 (2010) :Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Terabayashi, T., et al. J. Biol. Chem. 284(39):26716-26724(2009)Kim, J.G., et al. J. Korean Med. Sci. 24(3):443-447(2009)Lin, Z., et al. J. Biol. Chem. 283(48):33053-33058(2008)
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