|Other Names||Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Csk-binding protein, Transmembrane adapter protein PAG, Transmembrane phosphoprotein Cbp, PAG1, CBP, PAG|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.|
|Cellular Location||Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts|
|Tissue Location||Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a type IIItransmembrane adaptor protein that binds to the tyrosine kinase cskprotein. It is thought to be involved in the regulation of T cellactivation.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Yerly, S., et al. Eur. J. Haematol. 85(2):93-98(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Feng, X., et al. Oncogene 28(37):3320-3331(2009)
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