|Other Names||RGM domain family member B, DRG11-responsive axonal guidance and outgrowth of neurite, DRAGON, RGMB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1421b was selected from the RGMB region of human DRAGON (RGMB). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft|
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Provided below are standard protocols that you may find useful for product applications.
Repulsive Guidance Molecule B (RGMB) is primarily expressed in the central nervous system. RGM A and B both appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGMA appears in the neuroepithelium, and only RGMB in the peripheral nervous system. During development, both RGMA and B appear also in lung and in limb cartilage, while RGMB has additional expression domains in pancreas.
Schnichels,S., Gene Expr. Patterns 8 (1), 1-11 (2007)Metzger,M., Dev. Dyn. 234 (1), 169-175 (2005)Xia,Y., Endocrinology 146 (8), 3614-3621 (2005)
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