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DRAGON (RGMB) Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6NW40 |
|---|---|
| Other Accession | Q7TQ33 |
| Clone Names | 5111873 |
| Gene ID | 285704 |
|---|---|
| Other Names | RGM domain family member B, DRG11-responsive axonal guidance and outgrowth of neurite, DRAGON, RGMB |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1421b was selected from the RGMB region of human DRAGON (RGMB). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RGMB {ECO:0000303|PubMed:19324014, ECO:0000312|HGNC:HGNC:26896} |
|---|---|
| Function | Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q7TQ33}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q7TQ33}. Membrane raft {ECO:0000250|UniProtKB:Q7TQ33} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Repulsive Guidance Molecule B (RGMB) is primarily expressed in the central nervous system. RGM A and B both appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGMA appears in the neuroepithelium, and only RGMB in the peripheral nervous system. During development, both RGMA and B appear also in lung and in limb cartilage, while RGMB has additional expression domains in pancreas.
References
Schnichels,S., Gene Expr. Patterns 8 (1), 1-11 (2007)Metzger,M., Dev. Dyn. 234 (1), 169-175 (2005)Xia,Y., Endocrinology 146 (8), 3614-3621 (2005)
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