|Other Names||NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, Cell death regulatory protein GRIM-19, Complex I-B166, CI-B166, Gene associated with retinoic and interferon-induced mortality 19 protein, GRIM-19, Gene associated with retinoic and IFN-induced mortality 19 protein, NADH-ubiquinone oxidoreductase B166 subunit, NDUFA13, GRIM19|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091).|
|Cellular Location||Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus Note=Localizes mainly in the mitochondrion (PubMed:12628925). May be translocated into the nucleus upon IFN/RA treatment|
|Tissue Location||Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.|
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This gene encodes a subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), which functionsin the transfer of electrons from NADH to the respiratory chain.The protein is required for complex I assembly and electrontransfer activity. The protein binds the signal transducers andactivators of transcription 3 (STAT3) transcription factor, and canfunction as a tumor suppressor. The human protein purified frommitochondria migrates at approximately 16 kDa. Transcriptsoriginating from an upstream promoter and capable of expressing aprotein with a longer N-terminus have been found, but theirbiological validity has not been determined.
Sun, P., et al. J. Biol. Chem. 285(36):27545-27552(2010)Huang, Y., et al. Exp. Cell Res. 316(13):2061-2070(2010)Zhou, Y., et al. J. Interferon Cytokine Res. 29(10):695-703(2009)Lu, H., et al. Mol. Biol. Cell 19(5):1893-1902(2008)Yeo, W.M., et al. J. Virol. 82(2):1011-1020(2008)
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