NDUFA13 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9P0J0 |
---|---|
Clone Names | 100517017 |
Gene ID | 51079 |
---|---|
Other Names | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, Cell death regulatory protein GRIM-19, Complex I-B166, CI-B166, Gene associated with retinoic and interferon-induced mortality 19 protein, GRIM-19, Gene associated with retinoic and IFN-induced mortality 19 protein, NADH-ubiquinone oxidoreductase B166 subunit, NDUFA13, GRIM19 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NDUFA13 |
---|---|
Synonyms | GRIM19 |
Function | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091). |
Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus Note=Localizes mainly in the mitochondrion (PubMed:12628925). May be translocated into the nucleus upon IFN/RA treatment |
Tissue Location | Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), which functionsin the transfer of electrons from NADH to the respiratory chain.The protein is required for complex I assembly and electrontransfer activity. The protein binds the signal transducers andactivators of transcription 3 (STAT3) transcription factor, and canfunction as a tumor suppressor. The human protein purified frommitochondria migrates at approximately 16 kDa. Transcriptsoriginating from an upstream promoter and capable of expressing aprotein with a longer N-terminus have been found, but theirbiological validity has not been determined.
References
Sun, P., et al. J. Biol. Chem. 285(36):27545-27552(2010)Huang, Y., et al. Exp. Cell Res. 316(13):2061-2070(2010)Zhou, Y., et al. J. Interferon Cytokine Res. 29(10):695-703(2009)Lu, H., et al. Mol. Biol. Cell 19(5):1893-1902(2008)Yeo, W.M., et al. J. Virol. 82(2):1011-1020(2008)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.