|Other Names||Neuromedin-K receptor, NKR, NK-3 receptor, NK-3R, Neurokinin B receptor, Tachykinin receptor 3, TACR3, NK3R, TAC3R|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to a family of genes that function asreceptors for tachykinins. Receptor affinities are specified byvariations in the 5'-end of the sequence. The receptors belongingto this family are characterized by interactions with G proteinsand 7 hydrophobic transmembrane regions. This gene encodes thereceptor for the tachykinin neurokinin 3, also referred to asneurokinin B.
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Gianetti, E., et al. J. Clin. Endocrinol. Metab. 95(6):2857-2867(2010)Young, J., et al. J. Clin. Endocrinol. Metab. 95(5):2287-2295(2010)Fukami, M., et al. Horm Res Paediatr 73(6):477-481(2010)
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