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HCN1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O60741
Clone Names 100517107
Peptide ID 100517107
Additional Information
Gene ID 348980
Other Names Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, Brain cyclic nucleotide-gated channel 1, BCNG-1, HCN1, BCNG1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HCN1
Synonyms BCNG1
Function Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas.
Research Areas
Citations (0)

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Background

Hyperpolarization-activated cation channels of the HCNgene family, such as HCN1, contribute to spontaneous rhythmicactivity in both heart and brain.

References

Odefrey, F., et al. Cancer Res. 70(4):1449-1458(2010)Laurin, N., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (1), 95-103 (2009) :Woolcott, C.G., et al. Breast Cancer Res. 11 (1), R10 (2009) :Laurin, N., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (5), 600-605 (2008) :Tang, B., et al. Neurobiol. Dis. 29(1):59-70(2008)

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$ 80.00
Cat# BP14228b
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