|Other Names||Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, Brain cyclic nucleotide-gated channel 1, BCNG-1, HCN1, BCNG1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Hyperpolarization-activated cation channels of the HCNgene family, such as HCN1, contribute to spontaneous rhythmicactivity in both heart and brain.
Odefrey, F., et al. Cancer Res. 70(4):1449-1458(2010)Laurin, N., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (1), 95-103 (2009) :Woolcott, C.G., et al. Breast Cancer Res. 11 (1), R10 (2009) :Laurin, N., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (5), 600-605 (2008) :Tang, B., et al. Neurobiol. Dis. 29(1):59-70(2008)
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