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MAS1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P04201 |
|---|---|
| Clone Names | 100517117 |
| Gene ID | 4142 |
|---|---|
| Other Names | Proto-oncogene Mas, MAS1, MAS |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MAS1 |
|---|---|
| Synonyms | MAS |
| Function | Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The structure of the MAS1 product indicates that itbelongs to the class of receptors that are coupled to GTP-bindingproteins and share a conserved structural motif, which is describedas a '7-transmembrane segment' following the prediction that thesehydrophobic segments form membrane-spanning alpha-helices. The MAS1protein may be a receptor that, when activated, modulates acritical component in a growth-regulating pathway to bring aboutoncogenic effects.
References
Yang, J.K., et al. Diabetes Care 33(10):2271-2273(2010)Reis, A.B., et al. J. Mol. Histol. 41(1):75-80(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)Iwai, M., et al. Hypertens. Res. 32(7):533-536(2009)Vaz-Silva, J., et al. Reprod Sci 16(3):247-256(2009)
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