|Other Names||Proto-oncogene Mas, MAS1, MAS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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The structure of the MAS1 product indicates that itbelongs to the class of receptors that are coupled to GTP-bindingproteins and share a conserved structural motif, which is describedas a '7-transmembrane segment' following the prediction that thesehydrophobic segments form membrane-spanning alpha-helices. The MAS1protein may be a receptor that, when activated, modulates acritical component in a growth-regulating pathway to bring aboutoncogenic effects.
Yang, J.K., et al. Diabetes Care 33(10):2271-2273(2010)Reis, A.B., et al. J. Mol. Histol. 41(1):75-80(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)Iwai, M., et al. Hypertens. Res. 32(7):533-536(2009)Vaz-Silva, J., et al. Reprod Sci 16(3):247-256(2009)
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