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RNF19A Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9NV58
Clone Names 100517125
Peptide ID 100517125
Additional Information
Gene ID 25897
Other Names E3 ubiquitin-protein ligase RNF19A, 632-, Double ring-finger protein, Dorfin, RING finger protein 19A, p38, RNF19A, RNF19
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF19A
Synonyms RNF19
Function E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
Cellular Location Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients
Tissue Location Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system
Research Areas
Citations (0)

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The protein encoded this gene contains two RING-fingermotifs and an IBR (in between RING fingers) motif. This protein isan E3 ubiquintin ligase that is localized in Lewy bodies (LBs), acharacteristic neuronal inclusion in Parkinson's disease (PD)brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8,but not other ubiquitin-conjugating enzymes. This protein is foundto bind and ubiquitylate synphilin 1 (SNCAIP), which is ainteracting protein of alpha synuclein in neurons, and a majorcomponent of LB. Alternatively spliced transcript variants encodingthe same protein have been reported.


Huh, J.W., et al. Gene 424 (1-2), 63-70 (2008) :Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Ishigaki, S., et al. Neurobiol. Dis. 25(2):331-341(2007)Huang, Y., et al. J. Biol. Chem. 281(17):11610-11617(2006)Ishigaki, S., et al. J. Biol. Chem. 279(49):51376-51385(2004)

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$ 80.00
Cat# BP14232c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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