|Other Names||Regulator of G-protein signaling 9, RGS9, RGS9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity).|
|Cellular Location||Isoform 3: Membrane; Peripheral membrane protein. Note=Isoform 3 is targeted to the membrane via its interaction with RGS9BP.|
|Tissue Location||Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors)|
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This gene encodes a member of the RGS family of GTPaseactivating proteins that function in various signaling pathways byaccelerating the deactivation of G proteins. This protein isanchored to photoreceptor membranes in retinal cells anddeactivates G proteins in the rod and cone phototransductioncascades. Mutations in this gene result in bradyopsia. Multipletranscript variants encoding different isoforms have been found forthis gene.
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)Celver, J., et al. J. Neurochem. 114(3):739-749(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Greenbaum, L., et al. Psychiatr. Genet. 20(1):47-48(2010)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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