|Other Names||Neurotensin receptor type 2, NT-R-2, NTR2, Levocabastine-sensitive neurotensin receptor, NTSR2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in prostate (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the Gprotein-coupled receptor family that activate aphosphatidylinositol-calcium second messenger system. Binding andpharmacological studies demonstrate that this receptor bindsneurotensin as well as several other ligands already described forneurotensin NT1 receptor. However, unlike NT1 receptor, this generecognizes, with high affinity, levocabastine, a histamine H1receptor antagonist previously shown to compete with neurotensinfor low-affinity binding sites in brain. These activities suggestthat this receptor may be of physiological importance and that anatural agonist for the receptor may exist.
Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :Swift, S.L., et al. Cancer Res. 70(1):347-356(2010)Hwang, J.R., et al. Biochem. Biophys. Res. Commun. 391(1):1007-1013(2010)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
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