NTSR2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O95665 |
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Clone Names | 100517157 |
Gene ID | 23620 |
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Other Names | Neurotensin receptor type 2, NT-R-2, NTR2, Levocabastine-sensitive neurotensin receptor, NTSR2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NTSR2 |
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Function | Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Location | Expressed in prostate (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the Gprotein-coupled receptor family that activate aphosphatidylinositol-calcium second messenger system. Binding andpharmacological studies demonstrate that this receptor bindsneurotensin as well as several other ligands already described forneurotensin NT1 receptor. However, unlike NT1 receptor, this generecognizes, with high affinity, levocabastine, a histamine H1receptor antagonist previously shown to compete with neurotensinfor low-affinity binding sites in brain. These activities suggestthat this receptor may be of physiological importance and that anatural agonist for the receptor may exist.
References
Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :Swift, S.L., et al. Cancer Res. 70(1):347-356(2010)Hwang, J.R., et al. Biochem. Biophys. Res. Commun. 391(1):1007-1013(2010)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
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