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CNOT2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NZN8 |
|---|---|
| Clone Names | 100517176 |
| Gene ID | 4848 |
|---|---|
| Other Names | CCR4-NOT transcription complex subunit 2, CCR4-associated factor 2, CNOT2, CDC36, NOT2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CNOT2 |
|---|---|
| Synonyms | CDC36, NOT2 |
| Function | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4- NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a subunit of the multi-componentCCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis anddegradation and is also thought to be involved in mRNA splicing,transport and localization. The encoded protein interacts withhistone deacetylases and functions as a repressor of polymerase IItranscription. Alternatively spliced transcript variants have beenobserved for this gene.
References
Lau, N.C., et al. Biochem. J. 422(3):443-453(2009)Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008)Morita, M., et al. Mol. Cell. Biol. 27(13):4980-4990(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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