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CNOT2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9NZN8
Clone Names 100517176
Peptide ID 100517176
Additional Information
Gene ID 4848
Other Names CCR4-NOT transcription complex subunit 2, CCR4-associated factor 2, CNOT2, CDC36, NOT2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CNOT2
Synonyms CDC36, NOT2
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.
Cellular Location Cytoplasm. Nucleus
Tissue Location Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.
Research Areas
Citations (0)

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This gene encodes a subunit of the multi-componentCCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis anddegradation and is also thought to be involved in mRNA splicing,transport and localization. The encoded protein interacts withhistone deacetylases and functions as a repressor of polymerase IItranscription. Alternatively spliced transcript variants have beenobserved for this gene.


Lau, N.C., et al. Biochem. J. 422(3):443-453(2009)Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008)Morita, M., et al. Mol. Cell. Biol. 27(13):4980-4990(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)

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$ 80.00
Cat# BP14239c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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