|Other Names||LIM/homeobox protein Lhx6, LIM homeobox protein 6, LIM/homeobox protein Lhx61, Lhx6, Lhx61|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1423a was selected from the N-term region of human Lhx6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex.|
|Tissue Location||Brain specific. Expressed by neurons in the amygdala that are activated by reproductive olfactory stimuli and project in regions of the hypothalamus involved in reproduction (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Lhx6 is a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. This protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells.
Lopez-Bendito,G., J. Neurosci. 28 (7), 1613-1624 (2008)Ko,S.O., Dev. Biol. 312 (1), 435-447 (2007)Jepsen,K., Nature 450 (7168), 415-419 (2007)
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