|Other Names||Angiogenic factor with G patch and FHA domains 1, Angiogenic factor VG5Q, hVG5Q, G patch domain-containing protein 7, Vasculogenesis gene on 5q protein, AGGF1, GPATC7, GPATCH7, VG5Q|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPATC7, GPATCH7, VG5Q|
|Function||Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.|
|Cellular Location||Cytoplasm. Secreted. Note=Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted|
|Tissue Location||Widely expressed. Expressed in endothelial cells, vascular smooth muscle cells and osteoblasts. Expressed in umbilical vein endothelial cells and microvascular endothelial cells.|
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This gene encodes an angiogenic factor that promotesproliferation of endothelial cells. Mutations in this gene areassociated with a susceptibility to Klippel-Trenaunay syndrome.Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.
Fan, C., et al. J. Biol. Chem. 284(35):23331-23343(2009)Hu, Y., et al. Ann. Hum. Genet. 72 (PT 5), 636-643 (2008) :Gutierrez, S., et al. Am. J. Med. Genet. A 140(24):2832-2833(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Kihiczak, G.G., et al. Int. J. Dermatol. 45(8):883-890(2006)
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