|Other Names||Fetuin-B, 16G2, Fetuin-like protein IRL685, Gugu, FETUB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).|
|Tissue Location||Liver and testis.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the fetuinfamily, part of the cystatin superfamily of cysteine proteaseinhibitors. Fetuins have been implicated in several diversefunctions, including osteogenesis and bone resorption, regulationof the insulin and hepatocyte growth factor receptors, and responseto systemic inflammation. This protein may be secreted by cells.
Coen, G., et al. Am. J. Kidney Dis. 48(1):106-113(2006)Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)Wajih, N., et al. J. Biol. Chem. 279(41):43052-43060(2004)Hsu, S.J., et al. Genome 47(5):931-946(2004)Denecke, B., et al. Biochem. J. 376 (PT 1), 135-145 (2003) :
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