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LIME1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H400
Clone Names 100517211
Additional Information
Gene ID 54923
Other Names Lck-interacting transmembrane adapter 1, Lck-interacting membrane protein, Lck-interacting molecule, LIME1, LIME
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LIME1
Synonyms LIME
Function Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4- mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
Cellular Location Cell membrane; Single-pass type III membrane protein Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell
Tissue Location Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level)
Research Areas
Citations (0)
citation

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Background

LIME1 is a raft-associated transmembrane adaptorphosphoprotein that is preferentially expressed in hemopoieticcells, particularly T cells (Brdickova et al., 2003 [PubMed14610046]; Hur et al., 2003 [PubMed 14610044]).

References

Ahn, E., et al. Blood 107(4):1521-1527(2006)Tedoldi, S., et al. Blood 107(1):213-221(2006)Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)Brdickova, N., et al. J. Exp. Med. 198(10):1453-1462(2003)Hur, E.M., et al. J. Exp. Med. 198(10):1463-1473(2003)

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$ 277.78
Cat# BP14247b
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