|Other Names||Lck-interacting transmembrane adapter 1, Lck-interacting membrane protein, Lck-interacting molecule, LIME1, LIME|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.|
|Cellular Location||Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell|
|Tissue Location||Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
LIME1 is a raft-associated transmembrane adaptorphosphoprotein that is preferentially expressed in hemopoieticcells, particularly T cells (Brdickova et al., 2003 [PubMed14610046]; Hur et al., 2003 [PubMed 14610044]).
Ahn, E., et al. Blood 107(4):1521-1527(2006)Tedoldi, S., et al. Blood 107(1):213-221(2006)Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)Brdickova, N., et al. J. Exp. Med. 198(10):1453-1462(2003)Hur, E.M., et al. J. Exp. Med. 198(10):1463-1473(2003)
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