PAT2 (Slc36a2) Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8K415 |
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Clone Names | 5112871 |
Gene ID | 246235 |
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Other Names | Proton-coupled amino acid transporter 2, Proton/amino acid transporter 2, rPAT2, Solute carrier family 36 member 2, Tramdorin-1, Slc36a2, Pat2, Tramd1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1424b was selected from the Slc36a2 region of human PAT2 (Slc36a2). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Slc36a2 {ECO:0000312|RGD:620492} |
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Function | Electrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. Extension of the backbone length, as in beta-alanine and 4-aminobutanoate or methylation of the amino group, as in sarcosine and N,N- dimethylglycine, are also tolerated but decrease transport efficiency. A free carboxyl group is preferred. |
Cellular Location | Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BHK3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8BHK3} |
Tissue Location | Expressed in lung and spleen, and to a lower extent in brain, heart, kidney and skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
PAT2 is involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids amino acids such as glycine, alanine and proline. It is inhibited by sarcosine.
References
Bermingham,J.R. Jr., Mamm. Genome 15 (2), 114-125 (2004)Rubio-Aliaga,I., J. Biol. Chem. 279 (4), 2754-2760 (2004)Boll,M., Genomics 82 (1), 47-56 (2003)Boll,M., J. Biol. Chem. 277 (25), 22966-22973 (2002)
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