|Other Names||Transient receptor potential cation channel subfamily V member 3, TrpV3, Trpv3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1425a was selected from the N-term region of human Mouse TRPV3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in keratinocytes and hair follicles.|
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Provided below are standard protocols that you may find useful for product applications.
TRPV3 belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels.
Frederick,J., Biochem. Biophys. Res. Commun. 358 (4), 1058-1064 (2007)Asakawa,M., J. Invest. Dermatol. 126 (12), 2664-2672 (2006)
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