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AKT1S1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96B36
Clone Names 100528104
Peptide ID 100528104
Additional Information
Gene ID 84335
Other Names Proline-rich AKT1 substrate 1, 40 kDa proline-rich AKT substrate, AKT1S1 {ECO:0000312|EMBL:AAH160431}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKT1S1 {ECO:0000312|EMBL:AAH16043.1}
Function Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection.
Cellular Location Cytoplasm, cytosol. Note=Found in the cytosolic fraction of the brain.
Tissue Location Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A-549 and HeLa) than in normal cell lines (e.g. HEK293).
Research Areas
Citations (0)

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AKT1S1 is a proline-rich substrate of AKT (MIM 164730)that binds 14-3-3 protein (see YWHAH, MIM 113508) whenphosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[suppliedby OMIM].


Wang, L., et al. J. Biol. Chem. 283(23):15619-15627(2008)Fonseca, B.D., et al. Biochem. J. 411(1):141-149(2008)Fonseca, B.D., et al. J. Biol. Chem. 282(34):24514-24524(2007)Wang, L., et al. J. Biol. Chem. 282(27):20036-20044(2007)Sancak, Y., et al. Mol. Cell 25(6):903-915(2007)

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$ 80.00
Cat# BP14275b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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