|Other Names||G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6, Grk6, Gprk6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro) (By similarity).|
|Cellular Location||Membrane; Lipid-anchor.|
|Tissue Location||Expressed in the brain in striatal neurons.|
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Provided below are standard protocols that you may find useful for product applications.
Specifically phosphorylates the activated forms of G protein-coupled receptors (By similarity).
Chen, M., et al. J. Biol. Chem. 284(50):35040-35048(2009)Raehal, K.M., et al. Drug Alcohol Depend 104(3):187-196(2009)Murga, C., et al. Brain Behav. Immun. 23(1):16-17(2009)Tarrant, T.K., et al. Clin. Immunol. 129(1):115-122(2008)Loniewski, K., et al. Mol. Immunol. 45(8):2312-2322(2008)
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