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Mouse Mastl Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8C0P0
Clone Names 110316265
Peptide ID 110316265
Additional Information
Gene ID 67121
Other Names Serine/threonine-protein kinase greatwall, GW, GWL, Microtubule-associated serine/threonine-protein kinase-like, MAST-L, Mastl, Gw, Gwl
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mastl
Synonyms Gw, Gwl
Function Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes
Research Areas
Citations (0)

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Serine/threonine kinase. Mediates mitotic entry and maintenance. Maintains the correct equilibrium between cyclin B1-CDK1 and protein phosphatase 2A (PP2A) by promoting the inactivation of PP2A. Phosphorylates histone protein in vitro. May be involved in megakaryocyte differentiation (By similarity).


Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)Piao, Y., et al. Genome Res. 11(9):1553-1558(2001)

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$ 80.00
Cat# BP14289c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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