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Mouse Sgk3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9ERE3
Clone Names 110328081
Peptide ID 110328081
Additional Information
Gene ID 170755
Other Names Serine/threonine-protein kinase Sgk3, Cytokine-independent survival kinase, Serum/glucocorticoid-regulated kinase 3, Serum/glucocorticoid-regulated kinase-like, Sgk3, Cisk, Sgkl
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Sgk3
Synonyms Cisk, Sgkl
Function Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
Cellular Location Cytoplasmic vesicle. Early endosome. Recycling endosome Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Colocalizes with SLC9A3/NHE3 in the recycling endosomes (By similarity). Localized in vesicle-like structures and in the early endosome.
Tissue Location Widely expressed, predominantly in the heart, spleen and 7-day embryo
Research Areas
Citations (0)

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Sgk3 is involved in the activation of potassium channels (By similarity). Mediates cell IL-3-dependent survival signals. Can inhibit pro-apoptotic FOXO3A in vitro.


Zemtsova, I.M., et al. Am. J. Physiol., Cell Physiol. 299 (5), C1007-C1014 (2010) :Mauro, T.M., et al. FASEB J. 23(9):3193-3202(2009)Xu, J., et al. J. Biol. Chem. 284(21):14377-14385(2009)Campagna, D.R., et al. J. Invest. Dermatol. 128(3):730-732(2008)Okada, T., et al. Am. J. Pathol. 168(4):1119-1133(2006)

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$ 80.00
Cat# BP14298b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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