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OPN1SW Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P03999 |
|---|---|
| Clone Names | 110510043 |
| Other Names | Short-wave-sensitive opsin 1, Blue cone photoreceptor pigment, Blue-sensitive opsin, BOP, OPN1SW, BCP |
|---|---|
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | OPN1SW |
|---|---|
| Synonyms | BCP |
| Function | Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (Probable). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (By similarity). Involved in ensuring correct abundance and localization of retinal membrane proteins (By similarity). May increase spectral sensitivity in dim light (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Photoreceptor inner segment {ECO:0000250|UniProtKB:P51491}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P51491}. Cytoplasm, perinuclear region |
| Tissue Location | The three color pigments are found in the cone photoreceptor cells (PubMed:2937147). Expressed throughout the epidermis and dermis, primarily in the stratum granulosum in the facial and abdominal skin (at protein level) (PubMed:30168605). Expressed in dermal fibroblasts (at protein level) (PubMed:31380578). Expressed in melanocytes (at protein level) (PubMed:31730232) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene belongs to the G-protein coupled receptor 1family, opsin subfamily. It encodes the blue cone pigment genewhich is one of three types of cone photoreceptors responsible fornormal color vision. Defects in this gene are the cause of tritancolor blindness (tritanopia). Affected individuals lack blue andyellow sensory mechanisms while retaining those for red and green.Defective blue vision is characteristic.
References
Thirumuruganandham, S.P., et al. J Mol Model 15(8):959-969(2009)Ala-Laurila, P., et al. J. Biol. Chem. 284(24):16492-16500(2009)Tsutsumi, M., et al. Exp. Dermatol. 18(6):567-570(2009)Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)Fitzgibbon, J., et al. Hum. Genet. 93(1):79-80(1994)
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