|Other Names||Aryl hydrocarbon receptor nuclear translocator, ARNT protein, Class E basic helix-loop-helix protein 2, bHLHe2, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta, ARNT, BHLHE2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.|
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The aryl hydrocarbon (Ah) receptor is involved in theinduction of several enzymes that participate in xenobioticmetabolism. The ligand-free, cytosolic form of the Ah receptor iscomplexed to heat shock protein 90. Binding of ligand, whichincludes dioxin and polycyclic aromatic hydrocarbons, results intranslocation of the ligand-binding subunit only to the nucleus.Induction of enzymes involved in xenobiotic metabolism occursthrough binding of the ligand-bound Ah receptor to xenobioticresponsive elements in the promoters of genes for these enzymes.This gene encodes a protein that forms a complex with theligand-bound Ah receptor, and is required for receptor function.The encoded protein has also been identified as the beta subunit ofa heterodimeric transcription factor, hypoxia-inducible factor 1. At(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusionprotein, is associated with acute myeloblastic leukemia.Alternative splicing results in multiple transcript variants.
Otsubo, K., et al. Cancer Genet. Cytogenet. 202(1):22-26(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Kewley, R.J., et al. Biochem. Biophys. Res. Commun. 338(1):660-667(2005)Kewley, R.J., et al. Biochem. Biophys. Res. Commun. 338(1):660-667(2005)
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