|Other Names||Lethal(2) giant larvae protein homolog 2, HGL, LLGL2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.|
|Cellular Location||Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells|
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The lethal (2) giant larvae protein of Drosophila plays arole in asymmetric cell division, epithelial cell polarity, andcell migration. This human gene encodes a protein similar to lethal(2) giant larvae of Drosophila. In fly, the protein's ability tolocalize cell fate determinants is regulated by the atypicalprotein kinase C (aPKC). In human, this protein interacts withaPKC-containing complexes and is cortically localized in mitoticcells. Alternative splicing results in multiple transcript variantsencoding different isoforms.
Lisovsky, M., et al. Hum. Pathol. 41(6):902-909(2010)Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Yamada, Y., et al. Atherosclerosis 207(1):144-149(2009)Lisovsky, M., et al. Mod. Pathol. 22(7):977-984(2009)
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