|Other Names||Lethal(2) giant larvae protein homolog 2, HGL, LLGL2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.|
|Cellular Location||Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The lethal (2) giant larvae protein of Drosophila plays arole in asymmetric cell division, epithelial cell polarity, andcell migration. This human gene encodes a protein similar to lethal(2) giant larvae of Drosophila. In fly, the protein's ability tolocalize cell fate determinants is regulated by the atypicalprotein kinase C (aPKC). In human, this protein interacts withaPKC-containing complexes and is cortically localized in mitoticcells. Alternative splicing results in multiple transcript variantsencoding different isoforms.
Lisovsky, M., et al. Hum. Pathol. 41(6):902-909(2010)Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Yamada, Y., et al. Atherosclerosis 207(1):144-149(2009)Lisovsky, M., et al. Mod. Pathol. 22(7):977-984(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.