|Other Names||Ubiquitin-like-conjugating enzyme ATG10, 632-, Autophagy-related protein 10, APG10-like, ATG10, APG10L|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.|
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Provided below are standard protocols that you may find useful for product applications.
Autophagy is a process for the bulk degradation ofcytosolic compartments by lysosomes. ATG10 is an E2-like enzymeinvolved in 2 ubiquitin-like modifications essential forautophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261)conjugation and modification of a soluble form of MAP-LC3(MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to amembrane-bound form (Nemoto et al., 2003 [PubMed12890687]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Criollo, A., et al. Cell Death Differ. 14(5):1029-1039(2007)Shao, Y., et al. Autophagy 3(1):10-16(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Boya, P., et al. Mol. Cell. Biol. 25(3):1025-1040(2005)
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