|Other Names||Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MAPK/ERK kinase 5, MEK 5, MAP2K5, MEK5, MKK5, PRKMK5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||MEK5, MKK5, PRKMK5|
|Function||Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.|
|Tissue Location||Expressed in many adult tissues. Abundant in heart and skeletal muscle|
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This gene encodes a member of the dual specificity proteinkinase family, which functions as a mitogen-activated protein (MAP)kinase kinase. MAP kinases, also known as extracellularsignal-regulated kinases (ERKs), act as an integration point formultiple biochemical signals. This protein phosphorylates andactivates p38 MAP kinase in response to inflammatory cytokines orenvironmental stress. As an essential component of p38 MAP kinasemediated signal transduction pathway, this gene is involved in manycellular processes such as stress induced cell cycle arrest,transcription activation and apoptosis.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Huang, H.M., et al. J. Cell. Physiol. 223(3):687-694(2010)Sturchler, E., et al. Biochemistry 49(19):4094-4102(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Ding, N., et al. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21(10):597-600(2009)
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