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MAP2K5 Antibody (Center T315) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13163 |
|---|---|
| Clone Names | 109104 |
| Gene ID | 5607 |
|---|---|
| Other Names | Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MAPK/ERK kinase 5, MEK 5, MAP2K5, MEK5, MKK5, PRKMK5 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MAP2K5 |
|---|---|
| Synonyms | MEK5, MKK5, PRKMK5 |
| Function | Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). |
| Tissue Location | Expressed in many adult tissues. Abundant in heart and skeletal muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the dual specificity proteinkinase family, which functions as a mitogen-activated protein (MAP)kinase kinase. MAP kinases, also known as extracellularsignal-regulated kinases (ERKs), act as an integration point formultiple biochemical signals. This protein phosphorylates andactivates p38 MAP kinase in response to inflammatory cytokines orenvironmental stress. As an essential component of p38 MAP kinasemediated signal transduction pathway, this gene is involved in manycellular processes such as stress induced cell cycle arrest,transcription activation and apoptosis.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Huang, H.M., et al. J. Cell. Physiol. 223(3):687-694(2010)Sturchler, E., et al. Biochemistry 49(19):4094-4102(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Ding, N., et al. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21(10):597-600(2009)
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