|Other Names||Ribosomal RNA processing protein 1 homolog B, RRP1-like protein B, RRP1B, KIAA0179|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015).|
|Cellular Location||Nucleus, nucleolus Nucleus, nucleoplasm. Chromosome. Note=Predominantly located in the nucleolus with a small amount found in the nucleoplasm (PubMed:20926688). Associates with the perichromatin region during metaphase and with cytoplasmic foci during telophase before reaccumulation in the nucleolus during G2 (PubMed:20926688) Associates with heterochromatin and euchromatin (PubMed:19710015)|
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Provided below are standard protocols that you may find useful for product applications.
RRP1B belongs to the RRP1 family. It may be a novel susceptibility gene for breast cancer progression and metastasis.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Paik, J.C., et al. J. Biol. Chem. 285(9):6348-6363(2010)Crawford, N.P., et al. J. Biol. Chem. 284(42):28660-28673(2009)Hsieh, S.M., et al. Breast Cancer Res. 11 (5), R75 (2009) :Crawford, N.P., et al. PLoS Genet. 3 (11), E214 (2007) :
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