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Synthetic peptide
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- BACKGROUND
| Primary Accession | Q9GZQ8 |
|---|---|
| Clone Names | 100714002 |
| Peptide ID | 100714002 |
| Gene ID | 81631 |
|---|---|
| Other Names | Microtubule-associated proteins 1A/1B light chain 3B, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B light chain 3 B, MAP1A/MAP1B LC3 B, Microtubule-associated protein 1 light chain 3 beta, MAP1LC3B, MAP1ALC3 |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MAP1LC3B |
|---|---|
| Synonyms | MAP1ALC3 |
| Function | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. |
| Cellular Location | Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome Note=LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme (By similarity) |
| Tissue Location | Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene is a subunit of neuronalmicrotubule-associated MAP1A and MAP1B proteins, which are involvedin microtubule assembly and important for neurogenesis. Studies onthe rat homolog implicate a role for this gene in autophagy, aprocess that involves the bulk degradation of cytoplasmiccomponent.
References
Rouschop, K.M., et al. J. Clin. Invest. 120(1):127-141(2010)Kirkin, V., et al. Mol. Cell 33(4):505-516(2009)Othman, E.Q., et al. J. Clin. Lab. Anal. 23(4):249-258(2009)Liu, Q., et al. Ai Zheng 27(1):25-29(2008)Komatsu, M., et al. Cell 131(6):1149-1163(2007)
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