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ALDH2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P05091
Clone Names 70716007
Peptide ID 70716007
Additional Information
Gene ID 217
Other Names Aldehyde dehydrogenase, mitochondrial, ALDH class 2, ALDH-E2, ALDHI, ALDH2, ALDM
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1432c was selected from the Center region of human ALDH2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH2
Synonyms ALDM
Cellular Location Mitochondrion matrix.
Research Areas
Citations (0)

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Background

ALDH2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme.

References

Guo,Y.M., World J. Gastroenterol. 14 (9), 1444-1449 (2008)Chen,L., PLoS Med. 5 (3), E52 (2008)Teeguarden,J.G., Inhal Toxicol 20 (4), 375-390 (2008)Yoshida,A., Pharmacogenetics 2 (4), 139-147 (1992)

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$ 80.00
Cat# BP1432c
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