|Other Names||Nuclear transcription factor Y subunit beta, CAAT box DNA-binding protein subunit B, Nuclear transcription factor Y subunit B, NF-YB, NFYB, HAP3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is one subunit of atrimeric complex, forming a highly conserved transcription factorthat binds with high specificity to CCAAT motifs in the promoterregions in a variety of genes. This gene product, subunit B, formsa tight dimer with the C subunit, a prerequisite for subunit Aassociation. The resulting trimer binds to DNA with highspecificity and affinity. Subunits B and C each contain ahistone-like motif. Observation of the histone nature of thesesubunits is supported by two types of evidence; protein sequencealignments and experiments with mutants.
Stros, M., et al. Nucleic Acids Res. 37(7):2070-2086(2009)Kang, J.H., et al. J. Cell. Biochem. 104(4):1192-1203(2008)Raju, C.S., et al. Mol. Biol. Cell 19(7):3008-3019(2008)Di Agostino, S., et al. Cancer Cell 10(3):191-202(2006)Kahle, J., et al. Mol. Cell. Biol. 25(13):5339-5354(2005)
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