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FZD9 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O00144
Clone Names 100507051
Peptide ID 100507051
Additional Information
Gene ID 8326
Other Names Frizzled-9, Fz-9, hFz9, FzE6, CD349, FZD9, FZD3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD9
Synonyms FZD3
Function Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q9R216}; Multi-pass membrane protein. Note=Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. {ECO:0000250|UniProtKB:Q8K4C8}
Tissue Location Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney. Expressed in neural progenitor cells (PubMed:27509850)
Research Areas
Citations (0)

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Background

Members of the 'frizzled' gene family encode7-transmembrane domain proteins that are receptors for Wntsignaling proteins. The FZD9 gene is located within the Williamssyndrome common deletion region of chromosome 7, and heterozygousdeletion of the FZD9 gene may contribute to the Williams syndromephenotype. FZD9 is expressed predominantly in brain, testis, eye,skeletal muscle, and kidney.

References

Trubiani, O., et al. J. Cell. Physiol. 225(1):123-131(2010)Saus, E., et al. J Psychiatr Res (2010) In press :Fujimoto, T., et al. Int. J. Oncol. 35(4):861-866(2009)Kim, J.G., et al. J. Korean Med. Sci. 24(3):443-447(2009)Wang, H.X., et al. Mol. Hum. Reprod. 15(1):11-17(2009)

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$ 80.00
Cat# BP14338a
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