|Other Names||Synaptopodin, SYNPO, KIAA1029|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction, tight junction. Perikaryon Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses (By similarity)|
|Tissue Location||Expressed in cerebral cortex.|
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Synaptopodin is an actin-associated protein that may playa role in actin-based cell shape and motility. The namesynaptopodin derives from the protein's associations withpostsynaptic densities and dendritic spines and with renalpodocytes (Mundel et al., 1997 [PubMed 9314539]).[supplied byOMIM].
Kim, E.Y., et al. Am. J. Physiol. Renal Physiol. 299 (3), F594-F604 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Dai, S., et al. Nephrol. Dial. Transplant. 25(3):824-835(2010)Duning, K., et al. J. Am. Soc. Nephrol. 19(10):1891-1903(2008)Garovic, V.D., et al. Nephrol. Dial. Transplant. 22(4):1136-1143(2007)
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