|Other Names||Cadherin-related family member 5, Mu-protocadherin, Mucin and cadherin-like protein, CDHR5, MUCDHL, MUPCDH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a calcium-dependent cell adhesion protein.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a novel mucin-like gene that is a member ofthe cadherin superfamily. While encoding nonpolymorphic tandemrepeats rich in proline, serine and threonine similar to mucinproteins, the gene also contains sequence encoding calcium-bindingmotifs found in all cadherins. The role of the hybrid extracellularregion and the specific function of this protein have not yet beendetermined. Alternatively spliced transcript variants encodingdifferent isoforms have been described.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Goldberg, M., et al. Hum. Genet. 112(4):334-342(2003)Goldberg, M., et al. Am. J. Physiol. Renal Physiol. 283 (3), F454-F463 (2002) :Paris, M.J., et al. Genomics 69(2):196-202(2000)
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