|Other Names||Cadherin-related family member 5, Mu-protocadherin, Mucin and cadherin-like protein, CDHR5, MUCDHL, MUPCDH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.|
|Cellular Location||Apical cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein|
|Tissue Location||Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver (PubMed:12167596). Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level) (PubMed:24725409)|
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This gene is a novel mucin-like gene that is a member ofthe cadherin superfamily. While encoding nonpolymorphic tandemrepeats rich in proline, serine and threonine similar to mucinproteins, the gene also contains sequence encoding calcium-bindingmotifs found in all cadherins. The role of the hybrid extracellularregion and the specific function of this protein have not yet beendetermined. Alternatively spliced transcript variants encodingdifferent isoforms have been described.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Goldberg, M., et al. Hum. Genet. 112(4):334-342(2003)Goldberg, M., et al. Am. J. Physiol. Renal Physiol. 283 (3), F454-F463 (2002) :Paris, M.J., et al. Genomics 69(2):196-202(2000)
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