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MARCH1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8TCQ1
Clone Names 100416205
Peptide ID 100416205
Additional Information
Gene ID 55016
Other Names E3 ubiquitin-protein ligase MARCH1, 632-, Membrane-associated RING finger protein 1, Membrane-associated RING-CH protein I, MARCH-I, RING finger protein 171, MARCH1, RNF171
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RNF171
Function E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.
Cellular Location Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells.
Research Areas
Citations (0)

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MARCH1 is a member of the MARCH family of membrane-boundE3 ubiquitin ligases (EC MARCH proteins add ubiquitin(see MIM 191339) to target lysines in substrate proteins, therebysignaling their vesicular transport between membrane compartments.MARCH1 downregulates the surface expression of majorhistocompatibility complex (MHC) class II molecules (see MIM142880) and other glycoproteins by directing them to the lateendosomal/lysosomal compartment (Bartee et al., 2004 [PubMed14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart etal., 2008 [PubMed 18305173]).


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Thibodeau, J., et al. Eur. J. Immunol. 38(5):1225-1230(2008)De Gassart, A., et al. Proc. Natl. Acad. Sci. U.S.A. 105(9):3491-3496(2008)Bartee, E., et al. J. Virol. 78(3):1109-1120(2004)

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$ 80.00
Cat# BP14345c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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