|Other Names||26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit RPN1, 26S proteasome regulatory subunit S2, 26S proteasome subunit p97, Protein 5511, Tumor necrosis factor type 1 receptor-associated protein 2, PSMD2, TRAP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.|
|Tissue Location||Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta|
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Provided below are standard protocols that you may find useful for product applications.
The 26S proteasome is a multicatalytic proteinase complexwith a highly ordered structure composed of 2 complexes, a 20S coreand a 19S regulator. The 20S core is composed of 4 rings of 28non-identical subunits; 2 rings are composed of 7 alpha subunitsand 2 rings are composed of 7 beta subunits. The 19S regulator iscomposed of a base, which contains 6 ATPase subunits and 2non-ATPase subunits, and a lid, which contains up to 10 non-ATPasesubunits. Proteasomes are distributed throughout eukaryotic cellsat a high concentration and cleave peptides in anATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome,is the processing of class I MHC peptides. This gene encodes one ofthe non-ATPase subunits of the 19S regulator lid. In addition toparticipation in proteasome function, this subunit may alsoparticipate in the TNF signalling pathway since it interacts withthe tumor necrosis factor type 1 receptor. A pseudogene has beenidentified on chromosome 1.
Ikeda, Y., et al. J. Biol. Chem. 284(50):34889-34900(2009)Smith, L., et al. Neoplasia 11(11):1194-1207(2009)McCauley, J.L., et al. Genes Immun. 10(7):624-630(2009)Djakovic, S.N., et al. J. Biol. Chem. 284(39):26655-26665(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
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