|Other Names||Cystatin-A, Cystatin-AS, Stefin-A, Cystatin-A, N-terminally processed, CSTA, STF1, STFA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.|
|Tissue Location||Expressed in the skin throughout the epidermis.|
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Provided below are standard protocols that you may find useful for product applications.
The cystatin superfamily encompasses proteins that containmultiple cystatin-like sequences. Some of the members are activecysteine protease inhibitors, while others have lost or perhapsnever acquired this inhibitory activity. There are three inhibitoryfamilies in the superfamily, including the type 1 cystatins(stefins), type 2 cystatins, and kininogens. This gene encodes astefin that functions as a cysteine protease inhibitor, formingtight complexes with papain and the cathepsins B, H, and L. Theprotein is one of the precursor proteins of cornified cell envelopein keratinocytes and plays a role in epidermal development andmaintenance. Stefins have been proposed as prognostic anddiagnostic tools for cancer.
O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)Kestenbaum, B., et al. J. Am. Soc. Nephrol. 21(7):1223-1232(2010)Takai, T., et al. J. Immunol. 183(12):7958-7965(2009)Vasilopoulos, Y., et al. Eur. J. Hum. Genet. 16(8):1002-1009(2008)Parker, B.S., et al. J. Pathol. 214(3):337-346(2008)
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