|Other Names||Transcription initiation factor IIB, General transcription factor TFIIB, S300-II, GTF2B, TF2B, TFIIB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the general transcription factor IIB,one of the ubiquitous factors required for transcription initiationby RNA polymerase II. The protein localizes to the nucleus where itforms a complex (the DAB complex) with transcription factors IIDand IIA. Transcription factor IIB serves as a bridge between IID,the factor which initially recognizes the promoter sequence, andRNA polymerase II.
Wang, Y., et al. Curr. Biol. 20(6):548-553(2010)Thompson, N.E., et al. J. Biol. Chem. 284(37):24754-24766(2009)Gilman, B., et al. J. Biol. Chem. 284(14):9093-9098(2009)Vogt, C., et al. J. Virol. 82(22):11446-11453(2008)Elsby, L.M., et al. EMBO Rep. 7(9):898-903(2006)
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