|Other Names||Splicing factor 1, Mammalian branch point-binding protein, BBP, mBBP, Transcription factor ZFM1, Zinc finger gene in MEN1 locus, Zinc finger protein 162, SF1, ZFM1, ZNF162|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.|
|Tissue Location||Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a nuclear pre-mRNA splicing factor. Theencoded protein specifically recognizes the intron branch pointsequence and is required for the early stages of spliceosomeassembly. Alternate splicing results in multiple transcriptvariants.
Jeyabalan, J., et al. PLoS ONE 5 (5), E10646 (2010) :Corsini, L., et al. J. Biol. Chem. 284(1):630-639(2009)Rino, J., et al. Mol. Cell. Biol. 28(9):3045-3057(2008)Olejnik-Schmidt, A.K., et al. Arch. Virol. 153(5):983-990(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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