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IL33 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O95760
Clone Names 100507321
Peptide ID 100507321
Additional Information
Gene ID 90865
Other Names Interleukin-33, IL-33, Interleukin-1 family member 11, IL-1F11, Nuclear factor from high endothelial venules, NF-HEV, Interleukin-33 (95-270), Interleukin-33 (99-270), Interleukin-33 (109-270), IL33, C9orf26, IL1F11, NFHEV
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL33
Synonyms C9orf26, IL1F11, NFHEV
Function Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).
Cellular Location Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent
Tissue Location Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta
Research Areas
Citations (0)

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Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T helper type 2-associated cytokines.


Yagami, A., et al. J. Immunol. 185(10):5743-5750(2010)Masamune, A., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (4), G821-G832 (2010) :Melen, E., et al. J. Allergy Clin. Immunol. 126(3):631-637(2010)Corneveaux, J.J., et al. Hum. Mol. Genet. 19(16):3295-3301(2010)Yu, J.T., et al. Neurobiol. Aging (2010) In press :

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$ 80.00
Cat# BP14363a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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