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DLX5 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P56178 |
|---|---|
| Clone Names | 100517015 |
| Gene ID | 1749 |
|---|---|
| Other Names | Homeobox protein DLX-5, DLX5 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DLX5 |
|---|---|
| Function | Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of a homeobox transcriptionfactor gene family similiar to the Drosophila distal-less gene. Theencoded protein may play a role in bone development and fracturehealing. Mutation in this gene, which is located in a tail-to-tailconfiguration with another member of the family on the long arm ofchromosome 7, may be associated with split-hand/split-footmalformation.
References
Nakashima, N., et al. Brain Dev. 32(2):98-104(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Xu, J., et al. J. Biol. Chem. 284(31):20593-20601(2009)Kato, T., et al. Clin. Cancer Res. 14(8):2363-2370(2008)
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