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DLX5 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P56178
Clone Names 100517015
Peptide ID 100517015
Additional Information
Gene ID 1749
Other Names Homeobox protein DLX-5, DLX5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DLX5
Function Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}
Research Areas
Citations (0)

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This gene encodes a member of a homeobox transcriptionfactor gene family similiar to the Drosophila distal-less gene. Theencoded protein may play a role in bone development and fracturehealing. Mutation in this gene, which is located in a tail-to-tailconfiguration with another member of the family on the long arm ofchromosome 7, may be associated with split-hand/split-footmalformation.


Nakashima, N., et al. Brain Dev. 32(2):98-104(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Xu, J., et al. J. Biol. Chem. 284(31):20593-20601(2009)Kato, T., et al. Clin. Cancer Res. 14(8):2363-2370(2008)

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$ 80.00
Cat# BP14365c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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