|Other Names||Protein-arginine deiminase type-2, PAD-H19, Peptidylarginine deiminase II, Protein-arginine deiminase type II, PADI2, KIAA0994, PDI2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0994, PAD2, PDI2|
|Function||Catalyzes the deimination of arginine residues of proteins.|
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This gene encodes a member of the peptidyl argininedeiminase family of enzymes, which catalyze the post-translationaldeimination of proteins by converting arginine residues intocitrullines in the presence of calcium ions. The family membershave distinct substrate specificities and tissue-specificexpression patterns. The type II enzyme is the most widelyexpressed family member. Known substrates for this enzyme includemyelin basic protein in the central nervous system and vimentin inskeletal muscle and macrophages. This enzyme is thought to play arole in the onset and progression of neurodegenerative humandisorders, including Alzheimer disease and multiple sclerosis, andit has also been implicated in glaucoma pathogenesis. This geneexists in a cluster with four other paralogous genes. [provided byRefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Jang, B., et al. Acta Neuropathol. 119(2):199-210(2010)Cafaro, T.A., et al. Mol. Vis. 16, 1654-1658 (2010) :Hojo-Nakashima, I., et al. J. Biochem. 146(4):471-479(2009)Watanabe, Y., et al. J. Hum. Genet. 54(7):430-432(2009)
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