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CARD10 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BWT7
Clone Names 100517131
Additional Information
Gene ID 29775
Other Names Caspase recruitment domain-containing protein 10, CARD-containing MAGUK protein 3, Carma 3, CARD10, CARMA3
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CARD10
Synonyms CARMA3
Function Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR.
Cellular Location Cytoplasm.
Tissue Location Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney
Research Areas
Citations (0)
citation

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Background

The caspase recruitment domain (CARD) is a protein modulethat consists of 6 or 7 antiparallel alpha helices. It participatesin apoptosis signaling through highly specific protein-proteinhomophilic interactions. Like several other CARD proteins, CARD10belongs to the membrane-associated guanylate kinase (MAGUK) familyand activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM603517) (Wang et al., 2001 [PubMed 11259443]).

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Rehman, A.O., et al. Int J Oral Sci 1(3):105-118(2009)Martin, D., et al. J. Biol. Chem. 284(10):6038-6042(2009)

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$ 277.78
Cat# BP14373c
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