|Other Names||Caspase recruitment domain-containing protein 10, CARD-containing MAGUK protein 3, Carma 3, CARD10, CARMA3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Activates NF-kappa-B via BCL10 and IKK.|
|Tissue Location||Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The caspase recruitment domain (CARD) is a protein modulethat consists of 6 or 7 antiparallel alpha helices. It participatesin apoptosis signaling through highly specific protein-proteinhomophilic interactions. Like several other CARD proteins, CARD10belongs to the membrane-associated guanylate kinase (MAGUK) familyand activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM603517) (Wang et al., 2001 [PubMed 11259443]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Rehman, A.O., et al. Int J Oral Sci 1(3):105-118(2009)Martin, D., et al. J. Biol. Chem. 284(10):6038-6042(2009)
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