|Other Names||GDNF family receptor alpha-2, GDNF receptor alpha-2, GDNFR-alpha-2, GFR-alpha-2, GDNF receptor beta, GDNFR-beta, Neurturin receptor alpha, NRTNR-alpha, NTNR-alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, GFRA2, GDNFRB, RETL2, TRNR2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GDNFRB, RETL2, TRNR2|
|Function||Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
|Tissue Location||Isoform 1 is found in both brain and placenta.|
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Glial cell line-derived neurotrophic factor (GDNF) andneurturin (NTN) are two structurally related, potent neurotrophicfactors that play key roles in the control of neuron survival anddifferentiation. The protein encoded by this gene is a member ofthe GDNF receptor family. It is aglycosylphosphatidylinositol(GPI)-linked cell surface receptor forboth GDNF and NTN, and mediates activation of the RET tyrosinekinase receptor. This encoded protein acts preferentially as areceptor for NTN compared to its other family member, GDNF familyreceptor alpha 1. This gene is a candidate gene for RET-associateddiseases. Multiple transcript variants encoding different isoformshave been found for this gene.
Souza, R.P., et al. J Psychiatr Res 44(11):700-706(2010)Souza, R.P., et al. Psychopharmacology (Berl.) 210(3):347-354(2010)Buysschaert, I.D., et al. Allergy 65(5):616-622(2010)Lavedan, C., et al. Mol. Psychiatry 14(8):804-819(2009)Volpi, S., et al. J Clin Psychiatry 70(6):801-809(2009)
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