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ARIH2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O95376
Clone Names 100517136
Peptide ID 100517136
Additional Information
Gene ID 10425
Other Names E3 ubiquitin-protein ligase ARIH2, ARI-2, Protein ariadne-2 homolog, 632-, Triad1 protein, ARIH2, ARI2, TRIAD1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARIH2
Synonyms ARI2, TRIAD1 {ECO:0000303|PubMed:1611831
Function E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'-and 'Lys- 63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006).
Cellular Location Nucleus. Cytoplasm
Tissue Location Widely expressed with higher expression in granulocytes.
Research Areas
Citations (0)

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Background

E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.

References

Marteijn, J.A., et al. Leukemia 23(8):1480-1489(2009)Marteijn, J.A., et al. Blood 110(9):3128-3135(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Marteijn, J.A., et al. Blood 106(13):4114-4123(2005)Stelzl, U., et al. Cell 122(6):957-968(2005)

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$ 80.00
Cat# BP14375b
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